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Funding key, Gairdner winner says
Calgary researcher's discovery of stem cells in human brain was happy accident for scientist
Apr 16, 2008 04:30 AM
Sandro Contenta
Feature Writer - Toronto Star
Like many eureka moments in science, Samuel Weiss was looking
for one thing and discovered something else.
His discovery – that adult brains have stem cells
– has opened the door to possible cures for neurological
damage, including the kind suffered in strokes, multiple sclerosis
and spinal cord injuries.
Yesterday, the Calgary scientist was one of six researchers
given prestigious Gairdner International Awards at a luncheon in
Toronto.
Weiss' find 15 years ago has led him to a more recent
discovery – the potential of sexual attraction in repairing
damaged brain cells. And it has him warning against financial
starvation of basic research.
"The vast majority of new resources are going to applied
knowledge," Weiss, 52, said.
But without basic research, "ultimately the pipeline would go
dry (because) there will be fewer discoveries," said Weiss,
founding director of the Hotchkiss Brain Institute.
Weiss stumbled on his initial discovery while trying to keep
nerve cells from dying by adding a protein crucial to the life of
skin cells. What he instead found was that the protein made the
nerve cells divide.
"That accident, which was the consequence of a failed
experiment, turned out to be the discovery of neural stem cells,"
he said.
Stem cells are cells that divide and regenerate other cells.
They cause the skin to regenerate when it's cut or flakes off, for
example.
Before, it was believed stem cells didn't exist in adult
brains. The damage from a severe knock on the head, a stroke, or
Alzheimer's disease was believed to be permanent.
"The thought was that the brain didn't regenerate itself and
didn't repair itself," Weiss said. "Now we know it can."
Weiss published his team's findings in 1992. "When we tried
to get grants on (the research) everybody thought: `These guys in
Calgary ... maybe the elevation is a little high.'"
Last year, his team published test results showing that when
certain proteins are injected into mice that have suffered strokes,
stem cells move to regenerate the injured part of their brains.
Mice unable to use their left paw, for example, were suddenly able
to do so again.
The same procedure is currently being tested in human stroke
victims but hasn't as yet produced positive results, Weiss said.
Weiss' latest work suggests sexual attraction might also help
repair damaged brain cells.
When a lioness, for example, comes across the pheromone of a
dominant male, its brain produces new cells to store the memory of
the scent, Weiss found, so it can choose a proper mating partner.
The same capability is in the human brain, Weiss said, and
may prove a way to treat the mentally ill to improve their capacity
to bond.
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