THE GAIRDNER FOUNDATION 50TH ANNIVERSARY TORONTO SYMPOSIUM:

Wednesday, October 28- Friday, October 30, 2009

THE GAIRDNER FOUNDATION 50TH ANNIVERSARY TORONTO SYMPOSIUM:

Wednesday, October 28- Friday, October 30, 2009

WEDNESDAY, OCTOBER 28, 2009

9:00am-12:45pm- Stem Cells, Disease Mechanisms and Future Therapies

in collaboration with the McEwen Centre for Regenerative Medicine

Location: Macleod Auditorium, University of Toronto
Time: 9am -12:45 pm

Co-Chairs:       
Dr. Janet Rossant, Sick Kids Hospital, Toronto, ON
Dr. Gordon Keller, Director, McEwen Centre for Regenerative Medicine, UHN, Toronto

Introduction:  Dr. John Dirks, President and Scientific Director, the Gairdner Foundation

9.00-9:30         Shinya Yamanaka, Professor, Department of Stem Cell Biology, Institute for Frontier Medical Sciences, Kyoto University, Japan

Induction of pluripotency by defined factors

9.30-10:00        Gordon Keller, Director, McEwen Centre for Regenerative Medicine, Toronto, ON.

Directed differentiation of pluripotent stem cells to functional tissues

10.00-10:30      Andras Nagy, Senior Investigator Samuel Lunenfeld Research Institute, and Canada Research Chair in Stem Cells and Regeneration ,Toronto, ON

Transposon-mediated reprogramming provides a powerful exploratory tool for understanding  stem cell induction

10.30-10:45       Break

10.45-11:15      Mario Cappechi, Distinguished Professor of Human Genetics and Biology, University of Utah School of Medicine, Salt Lake City, Utah

Stem cells of the intestine

11.15-11:45       Phillip Sharp,Institute Professor, Massachusetts Institute of Technology, Boston MA

The roles of small RNAs in stem cells

11.45-12:15     Samuel Weiss, University of Calgary, AB

Adult neurogenesis and the formation of social memories

12.15-12:45      Oliver Smithies, Excellence Professor of Pathology and Laboratory Medicine, University of North Caroline, Chapel Hill, NC

On being a scientist for 60 years

1:15-4:45 - Gairdner Global Health Symposium

Location: Dalla Lana School of Public Health, University of Toronto
                        155 College Street, 6 ^th Floor
                          Toronto, ON
                          M5T 3M7
                          Canada

1:15-1:25                        
Introduction:                Dr. John Dirks , President & Scientific Director, The Gairdner Foundation
Welcome:                       Dr. Jack Mandel, Director, Dalla Lana School of Public Health, University of Toronto

The Global Health Stage

Chair:                                   Kiyoshi Kurokawa, Professor, National Graduate Institute for Policy Studies, Tokyo

1:25-1:40                           Jeff Koplan, Director of Global Health, Emory University
What's global health and why is it important?

1: 40-1:55                          Tachi Yamada, President of Global Health Program, Gates Foundation
Innovation and access in global health

1:55-2:10                            Mark Walport,Director, Wellcome Trust.
Building capacity

2:10-2:25                          Peter Singer, Director, McLaughlin-Rotman Centre for Global Health, University Health Network and University of Toronto
Global health: why Canada should care and what Canada should do.

2:25-2:45                          Discussion

2:45-3:00                          Break

The Challenge of Chronic Disease

Chair:                                  Alan Bernstein, Executive Director, Global HIV Vaccine Enterprise

3:00-3:20                          Nubia Munoz, Inaugural Canada Gairdner Global Health award recipient
Burden of cancer associated with infectious agents in developing countries.

3:20-3:35                          John Sulston, Cambridge, UK
What is Science for anyway?

3:35 -3:50                         Margaret G.  McGlynn, President, Merck Vaccines, Merck and Company Inc.      
The evolving global vaccine landscape

3:50-4:05                          Prabhat Jha , Director, Centre for Global Health Research, University of Toronto
Death and tobacco taxes

4:05-4:20                          Richard Peto,Professor of Medical Statistics and Epidemiology, Co-Director, CTSU,Oxford University
Halving adult mortality worldwide

4:20-4:40                          Discussion

4:40-4:45                          Conclusion
                                           Dr. John Dirks, President and Scientific Director, the Gairdner Foundation

1:30-4:45 -The Cell: An Endless Frontier

Location: Macleod auditorium, University of Toronto 

Co-Chairs: Corey Goodman, Past President, Biotherapeutics and Bioinnovation Center, Pfizer Inc.; San Francisco, CA

Howard Lipshitz, Professor & Chair, Department of Molecular Genetics, University of Toronto

1:30-1:40   Introduction

1:40-2:00pm    Elizabeth Blackburn, Morris Herzstein Endowed Professor in Biology & Physiology, Department of Biochemistry & Biophysics University of California, San Francisco                              
                            How cells  - and organisms - respond to perturbing their telomere maintenance

2:00-2:20pm    Ulrich Hartl, Max- Planck Institute for Biochemistry, Martinsried, Germany
                            The cellular machinery of protein folding: Molecular chaperones in health and disease

2:20-2:40           Avram Hershko, Technion Institute of Technology, Haifa
                            Roles of ubiquitin-mediated protein degradation in cellular regulation

2:40-2:55           Coffee Break

2:55-3:15pm      Bob Horvitz, David H. Koch Professor of Biology, Massachusetts Institute of Technology, Boston  and  Investigator, Howard Hughes Medical Institute                                                         
                             Genetic control of programmed cell death in C. elegans

3:15-3:35pm        Victor Ambros,Professor, Department of Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 
                               Small RNAs in every corner of the cell

3:35- 3:55             Gary Ruvkun,Professor of Genetics, Harvard Medical School
                              A C. elegans endocrine system that couples detection of xenobiotic drugs to regulation of reproduction and longevity 

3:55 - 4:15        Robert G. Roeder, Arnold and Mabel Beckman Professor, Laboratory of Biochemistry and Molecular Biology, Rockefeller University, NY
                            Transcriptional regulatory mechanisms in animal cells

4:15- 4:35pm     Richard Axel, Investigator, Howard Hughes Medical Institute and University Professor, Columbia University, NY                                                                                                                                         

                            Internal Representations of the Olfactory World

  4:35pm               Concluding Remarks

THURSDAY, OCTOBER 29, 2009

7:15 - 9:00am - Gairdner Industry Breakfast, Unclogging the Pipeline: Rejuvenating drug discovery

Location: MaRS Centre, MaRS Collaboration Centre Auditorium 

Moderator: Cal Stiller, Chair, Genome Canada/Bioquest Innovations Inc. /Ontario Institute for Cancer Research and Professor Emeritus, University of Western Ontario; Toronto, ON

Speakers:
Philip Sharp, Institute Professor, Massachusetts Institute of Technology; Cambridge, MA   
Corey Goodman, Past President, Biotherapeutics and Bioinnovation Center, Pfizer Inc.; San Francisco, CA 
David Baltimore, President Emeritus, Robert Andrews Millikan Professor of Biology, California Institute of Technology; Pasadena, CA

Please RSVP by email tothegairdner@gairdner.org, include the first and last name of the total number of guests attending.

9:00 - 3:15 -2009 Canada Gairdner Recipients' Lectures, The Charles Hollenberg Symposium

Location: JJR Macleod auditorium, University of Toronto 

9:00a.m. Dr John Dirks, Welcoming remarks

Chair: Dr. Catharine Whiteside, Dean, Faculty of Medicine, University of Toronto, Toronto, CA

9:15 -9:45am Dr. Peter Walter, Professor, Biochemistry & Biophysics, University of California, San Francisco and Investigator, Howard Hughes Medical Institute, CA,
Protein homeostasis in health and disease

9:45-10:15am Dr. Kazutoshi Mori, Professor, Department of Biophysics, Graduate School of Science, Kyoto University, Japan
The unfolded protein response: To mammals and beyond

10:15-10:30 Coffee Break

10:30-11:00am   Dr. Lucy Shapiro, Director, Beckman Center for Molecular and Genetic Medicine,Professor, Developmental Biology, Stanford University School of Medicine, Stanford, CA
The systems architecture of the bacterial cell cycle

11:00-11:30am    Dr. Richard Losick, Professor, Microbial Development and Gene Regulation, Harvard University, Cambridge, MA
Developmental biology of a simple organism

11:30-12:00pm   Dr. David Sackett, Professor Emeritus, Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, ON
On the tribulations of not performing randomized trials

12:00-1:00pm Lunch Break

1:00-1:15    John Dirks, Introduction of the Inaugural Canada Gairdner Global Health Award

Chair: Dr. Roderick MacKinnon, John D. Rockefeller Jr. Professor, Rockefeller University and Investigator, HHMI

1:15-1:45      Dr. Nubia Munoz, Emeritus Professor, National Cancer Institute, Bogota, Colombia and Visiting Scientist, Catalan Institute of Oncology, Barcelona
From causality to prevention: the case of cervical cancer

1:45-2:15     Dr. Shinya Yamanka, Professor, Department of Stem Cell Biology, Institute for Frontier Medical Sciences, Kyoto University, Japan
Induction of pluripotency by defined factors

2:15- 3:00   Dr. Sydney Brenner, Distinguished Professor, The Salk Institute, San Diego
Humanity's genes

3:00           Concluding Remarks

FRIDAY OCTOBER 30, 2009

Gairdner/Nobel and Gairdner Laureate Forums

Location: Convocation Hall, University of Toronto
All sessions will present a moderated panel discussion, followed by Q&A from the audience.

Friday's events are free but registration is required. Click here.

8:30-8:45        Introduction and Welcome
Dr. John Dirks, President and Scientific Director, Gairdner Foundation
Dr. Alain Beaudet, President, CIHR
Dr. David Naylor, President, University of Toronto

8:45-10:15am   Attack and Repulsions: Infections and the Immune System

Moderator and Introduction:Dr. David Baltimore, Robert Andrews Millikan Professor of Biology, California Institute of Technology, CA

Speakers and Titles:

Dr. Ralph Steinman, Henry G. Kunkel  Professor & Sr. Physician, The Rockefeller University, New York
New Vaccines: Doing Better than Nature

Dr. Emil Unanue, Paul & Ellen Lacy Professor, Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO
 Is understanding peptide selection by histocompatibility molecules important for vaccination?

Dr. Rolf Zinkernagel, University of Zurich, Zurich, Switzerland
New Vaccines: Hopes and Hypes

10:30-12:00pm  The Metabolic Syndrome: Food and Fuel for Thought

Moderator and Introduction:Dr. Joe Goldstein, Regental Professor, University of Texas Southwestern Medical Center, Dallas, TX

Speakers and Titles:

Dr. Jeff Friedman, Marilyn M. Simpson Professor, The Rockefeller University, New York Leptin and Obesity

Dr. Ron Evans, Professor, Salk Institute for Biological Studies, La Jolla California
Nuclear Receptors and Energy 

Dr. Michael Brown, Regental Professor, University of Texas Southwestern Medical Center, Dallas, TX
SREBP Pathway and Cholesterol 

Dr. Tony Pawson, University Professor, Program in Molecular Biology & Cancer, Samuel Lunenfeld Research Institute, Toronto
Targeting Metabolic Networks

2:00-3:30pm   Cancer: Can New Insights into Biology Yield Better Results?

Moderator and Introduction:Dr. Michael Bishop Chancellor, University of California, San Francisco

Speakers and Titles:

Dr.Harald zur Hausen, Professor Emeritus, German Cancer Research institute, Heidelberg, Germany            
  Insights in virology as precondition for novel approaches in the prevention of human cancers

Dr.Dennis Slamon, Chief, Department of Hematology, Oncology, University of California, Los Angeles
Molecular diversity of human breast cancer: clinical and threapeutic implications

Dr. Bob Weinberg, Professor of Biology, Member, Whitehead Institute, MIT, Cambridge, MA Do cancer stem  cells and metastasis hold the answers?

Dr. Barry Marshall, International Research Foundation for Helicobacter and Intestinal Immunology, Virginia
           Helicobacter and stomach cancer
Dr. Elizabeth Blackburn, Morris Herzstein Endowed Professor, Biochemistry & Biophysics, University of California, San Francisco
            Telomeres and telomerase in cancer

7:00- 8:30pm The Personalized Genome: Do I Want to Know?

Supported by an education grant from Eli Lilly Canada Inc.

Dr. Michael Hayden, Director and Senior Scientist, Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver
Dr. Sydney Brenner, Distinguished Professor, The Salk Institute, San Diego
Charles Sabine, Award winning NBC News correspondent and carrier of the gene for Huntington's Disease
Dr. George Church, Professor of Genetics, Harvard Medical School, Boston, MA

If you need more information please contact Sheila Robinson at sheila.robinson@gairdner.org

The Gairdner Foundation gratefully acknowledges the generous support of our major sponsors:

Our thanks to the following:

Sunnybrook Hospital

Canadian Foundation for Innovation

Genome Canada

Global Health Research Initiative

Eli Lilly Canada Inc.

Updated: October 15, 2009