Director of the Centre for Gene Therapeutics in the Institute for Molecular Medicine and Health
McMaster University, Hamilton, Ontario

Dr. Jack Gauldie received B.Sc. from McMaster in Chemistry in 1964 and Ph.D. from University College, London, England in 1968.  Since 1970 has been at McMaster University, Faculty of Health Sciences in the Department of Pathology and Molecular Medicine. He was Chair of the Department from 1989 - 2004.

In research, he is active in the Molecular Virology and Immunology Program where his interests have focused on the molecular mechanisms involved in the control of acute and chronic inflammation and immunity. His discovery of IL-6 and the IL-6 family of cytokines as the major regulator of the hepatic acute phase response in inflammation is part of the ongoing studies in cytokine/cytokine receptor biology.  Cell and molecular studies in chronic inflammatory and fibrotic disorders including pulmonary fibrosis and asthma and the characterization of the cell and molecular biology of the myofibroblast are also a current focus of his research group. Most recently, he has collaborated with Dr. Frank Graham in the use of recombinant adenovirus vectors to deliver growth factors, cytokine genes and co-stimulatory molecules for adjuvant approaches to mucosal immune regulation and immunotherapy of cancer. Animal studies have progressed to human gene therapy trials in breast cancer and melanoma with vectors expressing IL-2 and IL-12 and with dendritic cells loaded with tumor antigen genes. All trials have involved either direct immune stimulation or specific antigen immunization with cell based vaccines.

He is a member of the Advisory Board of the Institute for Infection and Immunity of CIHR and a member of the Research Management Committee of CANVAC, the Canadian Network for Vaccines and Immunotherapeutics . He is the target leader for cancer vaccines with CANVAC.

Recent awards include:
1993        Distinguished Alumni Scholar Award, McMaster University
1997        Fellow, Royal Society of Canada
1998        Bernhard Cinader Award, The Canadian Society for Immunology
1998        Medal of Honour, Canadian Medical Association
1999        Who's Who in Healthcare Award
2002        Ortho Clinical Diagnostics Award, Ontario Society of Clinical Chemists
2004        Canadian Society of Clinical Chemists Research Excellence Award

Born in Greenock, Scotland
Married with 2 sons