Distinquished Professor in the Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel. Dr. Hershko obtained his M.D. degree from the Hebrew University-Hadsassah Medical School in 1965 and his Ph.D. degree in 1969 from Hebrew University. He carried out post-doctorial research at the University of California Medical Centre, San Francisco from 1969 to 1971. Dr. Hershko has pursued his research on intracellular proteolysis at the Technion, where he was appointed Associate Professor in 1972, Professor in 1980 and Distinquished Professor in 1998. Through rigorous biochemical experimentation, Dr. Hershko discovered the role of ubiquitin modification in energy dependent proteolysis and defined the enzymatic machinery that catalyzes ubiquitin conjugation. Since 1987, he has been a member of the Rappaport Institute for Research in the Medical Sciences, and Member, European Molecular Biology Organization (EMBO) since 1993. Dr. Hershko was awarded the Weizmann Prize in 1987 and the Israel Prize in 1994.