The Medical Advisory Board (MAB) comprises a group of scientists from across Canada, the United States, Europe, Asia and Australia. Each January, the MAB meets in Toronto to review the nominations submitted by the Medical Review Panel. After an in depth study and lengthy discussion of each nominee, comparing their work with others in their respective field, secret ballots are cast and the five or six annual winners chosen.

The members of the Medical Advisory Board are:

John H. Dirks, M.D. (Chair) The Gairdner Foundation, Toronto, ON               
John Bell, D.M. F.R.C.P. Oxford University, UK
Sydney Brenner, D.Phil. F.R.S. The Salk Institute, San Diego, CA, USA
Linda B. Buck, Ph.D.  Howard Hughes Medical Institute, Seattle, WA, USA
John R. G. Challis, D.Sc., Ph.D., F.R.S.C. University of Toronto, Toronto, ON
David Colman, Ph.D. Montreal Neurological Institute, Montreal, QC
Peter C. Doherty, Ph.D. The University of Melbourne, Melbourne, AU
Victor Dzau, M.D. Duke Hospital South, Durham, NC, USA
Cyril B. Frank, M.D. University of Calgary, Calgary, AB
Jack Gauldie, Ph.D. (Co-Chair, MRP) McMaster University, Hamilton, ON
Michael Hayden, PhD. University of British Columbia, Vancouver, BC
F. Ulrich Hartl, Professor M.D. Max-Plank-Insitut, Munich, Germany
Robert Horvitz, Ph.D. Massachusetts Institute of Technology, Cambridge, USA
Peter Lewis, Ph.D. (Co-Chair MRP) University of Toronto, Toronto, ON
Victor Ling, Ph.D. BC Cancer Research Centre, Vancouver, BC
Anthony J. Pawson, Ph.D. University of Toronto, Toronto, ON
Ronald E. Pearlman, Ph.D. York University, Toronto, ON
Janet Rossant, Ph.D. University of Toronto, Toronto, ON
Guy Rouleau, M.D., PhD. Université de Montréal
Phillip A. Sharp, Ph.D. Massachusetts Institute of Technology, Boston, MA, USA
J. G. P. Sissons, M.D., F.R.C.P., F.R.C. Path., University of Cambridge, Cambridge, UK
Lap-Chee Tsui, Ph.D. F.R.S. F.R.S.C. University of Hong Kong, Hong Kong
D. Lorne Tyrrell, M.D. Ph.D. University of Alberta, Edmonton, AB
Michael Tyers, Ph.D. University of Edinburgh, UK