Alfred G. Knudson Jr.

MD PhD

1922-2016

Philadelphia, PA, USA

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For his development of a two-hit mutational hypothesis for the origin of cancer that related hereditary and non-hereditary forms of retinoblastoma and other tumors; this hypothesis has become a paradigm for mutational theories on the origins of cancer and led directly to the concept of suppressor oncogenes.

† 1922-2016

Alfred G. Knudson Jr.

Canada Gairdner International Award