Timothy A. Springer

PhD

Latham Family Professor of Biological Chemistry and Molecular Pharmacology, Professor of Medicine, Harvard Medical School and Boston Children’s Hospital; Chairman, Institute for Protein Innovation

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For discovery of the first immune system adhesion molecules, elucidation of their roles in antigen recognition and leukocyte homing, and translation of these discoveries into therapeutics for autoimmune diseases

The Work:

Dr. Timothy Springer’s work has changed understanding of cell-to-cell interactions that control immune responses and the movement of leukocyte subsets out of the vasculature into tissues. He discovered the first examples of cell recognition receptors and counter-receptors and the first family of integrins. He subsequently showed molecularly how integrins transmit signals between the exterior and interior of cells and enable cell movement. He opened the way for the first therapeutic use of antibodies to cell-cell recognition receptors to treat autoimmune diseases.

The Impact:

Dr. Springer’s discoveries and world-renowned work have transformed the fields of cell biology and immunology. His discoveries and entrepreneurship have led to an important new class of therapeutics for multiple autoimmune diseases including Psoriasis, Multiple Sclerosis, Ulcerative Colitis, Crohn’s Disease and cancer.